NOTCH1 and noise induced hearing loss: We found that the haplotype AAC (rs3124594-rs3124599-rs3124603) in the Notch1 gene was associated with an increased risk of NIHL (OR = 14.95), whereas the haplotype GGC and GGT were associated with a decreased risk for NIHL (OR = 0.11 and 0.02) compared with GAC.