Recently, the mitochondrial biogenesic effects of resveratrol on the SIRT1/PGC-1α pathway was also observed in an in vitro model of endothelial cells [22] and in vivo, in the aorta of T2D mice, as well as in heart of transgenic rats expressing human renin and angiotensinogen genes [23]. This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.