LRAT and Hepatic fibrosis: Finally, mice deficient for the lecithin retinol acyltransferase (Lrat) gene, encoding an enzyme converting retinol to its RE storage form [14], lack RE-filled LDs but are not predisposed to spontaneous or acute exacerbation of fibrogenesis, suggesting that the loss of LDs may not be sufficient to trigger liver fibrosis [14,15].