This is mediated by the release of ROS that decreases the expression of the specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes which are involved in cancer cell proliferation (hepatocyte growth factor receptor (c-Met), epidermal growth factor receptor and cyclin D1), survival (survivin and bcl-2) and angiogenesis (vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2)) [25]. The gene discussed is SP4; the disease is cancer.