Another mechanism for inducing apoptosis by AA in colon cancer cells (HCT-8) is through an increase in the calcium influx in the endoplasmic reticulum, the translocation of Bad to the mitochondria from the cytosol after dissociation from 14-3-3β and an increase in the expression of Bax [26]. The gene discussed is BAD; the disease is malignant colon neoplasm.