Correspondingly to studies by Harazono et al. in the PDAC cell line Panc-1 and in esophageal squamous cell carcinoma tissue highlighting ZEB-1 as a target of microRNA-655, we identified circulating microRNA-655 as an EMT-suppressive microRNA correlating significantly with improved overall survival in PDAC patients [27]. The gene discussed is ZEB1; the disease is esophageal squamous cell carcinoma.