In the research, a total of 21,470 patients without liver diseases were treated with 11 independent herbal TCMs, such as Bupleuri radix, Scutellaeiae radix, and Glycyrrhizae radix, etc. Finally, 26 patients (0.12%) experienced high values of ALT (≥5 × upper limit of normal). The gene discussed is GPT; the disease is liver disorder.