Also, studies have shown that abrogation of the JAK/STAT pathway can induce cell-arrest and apoptosis in vitro [53], inhibit tumor growth, achieve tumor elimination with significantly improved survival in murine models of human HL [54], and can significantly improve progression-free survival time specifically in patients with relapsed or treatment refractory HL [55]. This evidence concerns the gene SOAT1 and Hodgkins lymphoma.