STAT3 and Miyoshi myopathy: STAT3 activation has been reported to contribute to MM progression both directly by upregulating survival and anti-apoptotic target genes [65], as well as indirectly by activating myeloid derived suppressor-cells (MDSCs) in the bone marrow (BM) microenvironment, which causes T-cell suppression (immunosuppression) and facilitates tumor progression [66].