STAT3 and diffuse large B-cell lymphoma: Involvement of the STAT3 oncogene has also been reported in diffuse large B-cell lymphoma (DLBCL) [58] and inhibition of STAT3 by targeted oligonucleotides have been shown to exert a therapeutic effect against human DLBCL xenotransplants in nude mice and to inhibit their growth by a direct cytotoxic/cytostatic effect [59].