Calcitriol up-regulates MKP5 expression, leading to subsequent inhibition of the production of pro-inflammatory cytokines, such as IL-6, by interfering with the signaling of pleiotropic inflammatory cytokines, such as TNFα, supporting a role for calcitriol in the prevention and/or early treatment of PCa [63]. The gene discussed is IL6; the disease is posterior cortical atrophy.