Although not as intensely studied, NRP‐2 is involved in cell survival signaling, migration, invasion, and anchorage‐independent growth in pancreatic cancer cells.74 A study exhibiting NRP‐2 knockdown demonstrated significant reductions in these functions in vitro and in vivo using BxPC‐3 cells that naturally overexpresses NRP‐2.74 Despite the fact that proliferation was unchanged following NRP‐2 knockdown in BxPC‐3, subcutaneous tumor proliferation in mice was remarkably reduced in the same study. This evidence concerns the gene NRP2 and neoplasm.