NRP2 and neoplasm: Early metastatic events are caused by the activation of lymphangiogenic coreceptor VEGFR3 when activated by its appropriate ligands VEGF‐C and VEGF‐D.10, 80 On the other hand, its role in tumor angiogenesis has been described in mouse models, whereby NRP‐2 antibody reduced metastasis in a lung tumor model.81 As such, it is recommended that NRP‐2‐mediated lymphangiogenesis in PDAC is investigated to obtain a greater understanding of its metastatic potential via manipulation of the lymphatics.82, 83