AKT1 and neoplasm: Moreover, it may also be worth investigating the role of the Akt pathway, as activated Akt was reduced in NRP‐2‐depleted cells.74 However, the knockdown of NRP‐2 via shRNA did not reduce tumor mass in a murine xenograft model;75 differences could be explained by K‐Ras mutation in ASPC‐1 compared to wild‐type K‐Ras in BxPC‐3.