NRP1 and neoplasm: In this event, the tumor exploits its microenvironment by releasing signaling molecules, such as cytokines and growth factors, to activate surrounding quiescent cells, leading to an uncontrollable series of events.56 Ben et al34 suggested that NRP‐1 upregulation in PDAC was associated with increased angiogenesis due to a significantly positive correlation between NRP‐1 expression and microvessel density in PDAC tissues resected from patients.