On the other hand, knockdown of NRP‐1 in cell line FG significantly increased susceptibility to gemcitabine and 5‐FU.42, 43 In another study, NRP‐1 overexpression augmented MCL‐1 expression, indicating a mechanism to evade apoptosis.41 Interestingly, constitutive MAPK signaling promoted survival and inhibition of anoikis in other cancer cell types44—perhaps, this system may explain the increased survival. This evidence concerns the gene NRP1 and cancer.