Although blocking NRP‐1 seemed to enhance the effect of anti‐VEGF therapy in reducing microvessel density of the pancreatic tumor environment,58 additional studies are required to investigate whether VEGF signaling alone or in combination with other signaling molecules overexpressed by pancreatic cancer that could interact with NRP‐1 is responsible for enhanced tumor angiogenesis. This evidence concerns the gene VEGFA and familial pancreatic carcinoma.