In a zebrafish extravasation model using pancreatic cancer cell line ASPC‐1 that expresses NRP‐2, a reduction in NRP‐2 diminished extravasation, which speaks to the metastatic potential conferred by NRP‐2.75 In addition, the study suggested that vascular adhesion is mediated by the interaction between NRP‐2 on PDAC cells and α5 Integrin on endothelial cells, as demonstrated by atomic force microscopy. This evidence concerns the gene NRP2 and familial pancreatic carcinoma.