Elevated FoxO1 production in the liver augments hepatic apoC‐III expression, resulting in increased plasma TG levels and impaired fat tolerance.48 In addition, transgenic mice expressing a constitutively nuclear FoxO1 allele directly exhibited hypertriglyceridaemia.48 These results provide several lines of evidence that FoxO1 functions as a regulator of lipogenesis and TG metabolism through different pathways. Here, FOXO1 is linked to hypertriglyceridemia.