Indeed, pathological changes in the metabolic and physiological status of the liver such as NAFLD, NASH, injury, and cirrhosis, result in the onset of liver cancer, including HCC.116, 117 Here, we review and discuss recent advances in the elucidation of cellular and molecular alterations, signalling pathways associated with PCAF, and their effects on hepatocarcinogenesis and tumour growth. The gene discussed is KAT2B; the disease is metabolic dysfunction-associated steatohepatitis.