AKT1 and Insulin resistance: Taken together, as PTEN and TRB3 inhibit the PI3K‐Akt/PKB signalling pathway, the acetylation status of PTEN and TRB3 and the balance between PCAF and HDAC activities also explain their role in insulin resistance and increased gluconeogenesis, which may indicate an involvement of PCAF‐induced acetylation and hepatic insulin resistance (Figure 2B).