In 1898, Naunyn coined the term hepatogenous diabetes to describe the coincidence between diabetes and liver glucose disorder, emphasizing the pathological importance of the liver in regulating glucose metabolism.75 Several transcription factors and co‐activators are involved in the nutritional and hormonal control of gluconeogenesis, including PGC‐1α and FoxO1. The gene discussed is PPARGC1A; the disease is diabetes mellitus.