Studies have suggested that the targeted inhibition of Gli1 promotes the growth inhibition of HCC with activated hedgehog signalling which has been observed in various human malignancies.121, 122 Li et al observed that PCAF was down‐regulated in HCC tissues compared with the adjacent nontumour tissues and significantly associated with malignant portal vein invasion. This evidence concerns the gene GLI1 and hepatocellular carcinoma.