The long‐term state of hyperlipidaemia leads to liver pathologies referred to as nonalcoholic fatty liver disease (NAFLD), which represents a large spectrum of diseases, including hepatic steatosis, fatty liver, and nonalcoholic steato hepatitis (NASH).56, 57, 58, 59 Deciphering the specific activities and substrates of PCAF mediating its different physiological functions in NAFLD has become an important area of research, as these functions may not only be limited to acetylation. The gene discussed is KAT2B; the disease is metabolic dysfunction-associated steatohepatitis.