Studies have shown that S‐phase kinase‐associated protein 2 (Skp2), which is involved in the regulation of glucose metabolism, interacts with ubiquitinases and promotes the degradation of FoxO1 through the Akt‐specific phosphorylation of Serine 256, thus suppressing the effects of this protein.82 This result suggests that the ubiquitination and degradation of FoxO1 by Skp2 may contribute to the onset of insulin resistance and diabetes. This evidence concerns the gene SKP2 and diabetes mellitus.