KAT2B and neoplasm: In vivo experiments have confirmed that PCAF‐induced autophagy inhibits tumour growth.119 Notably, subsequent in vitro experiments have shown that PCAF promotes autophagy by inhibiting Akt/mTOR signalling pathway, which was well studied in the past decades as a negative pathway of autophagy.119 In this study, PCAF expression inhibited the phosphorylation of Akt and mTOR kinase, whereas knockdown of PCAF stimulated Akt and mTOR kinase activity.