The liver is a significant insulin‐sensitive organ in the regulation of glucose homeostasis.86, 87 Thus, insulin resistance in the liver was suggested as an underlying cause of metabolic syndrome, including hyperglycaemia, dyslipidaemia, and increased inflammatory factors.87 PI3‐kinase is a downstream target of insulin signalling, and its inhibition leads to hepatic insulin resistance. This evidence concerns the gene INS and metabolic syndrome.