In vivo experiments have confirmed that PCAF‐induced autophagy inhibits tumour growth.119 Notably, subsequent in vitro experiments have shown that PCAF promotes autophagy by inhibiting Akt/mTOR signalling pathway, which was well studied in the past decades as a negative pathway of autophagy.119 In this study, PCAF expression inhibited the phosphorylation of Akt and mTOR kinase, whereas knockdown of PCAF stimulated Akt and mTOR kinase activity. This evidence concerns the gene AKT1 and neoplasm.