For example, PCAF can acetylate nonhistone proteins, including, phosphoglycerate kinase 1 (PGK1) (K323), ATP‐citrate lyase (ACLY) (K540, K546, and K554), Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC1‐α) (K328 and K450), forkhead box P3 (FOXP3), and p53, etc.37, 38, 39, 40, 41 Additionally, increasing evidence demonstrates that PCAF is not only a HAT but also shows other effects such as ubiquitination.42 This review primarily focuses on the different mechanisms by which PCAF fine‐tunes hepatic metabolic syndrome, inflammatory disease, and tumour growth. This evidence concerns the gene KAT2B and neoplasm.