A functional study demonstrated that Gli1, as a direct negative target of PCAF, induced EMT and promoted tumour metastasis and invasions.120 As an antioncogene, PCAF works significantly in the development of HCC by suppressing HCC cell metastasis and EMT by targeting Gli1, indicating the value of PCAF for the suppression of HCC metastasis (Figure 4A). The gene discussed is KAT2B; the disease is hepatocellular carcinoma.