Interestingly, an overexpression of FFP synthase, the primary target of BPs, induced cardiac hypertrophy and HF in mice.44 Furthermore, inhibition of FPP synthase attenuates hypertrophy in neonatal rat cardiomyocytes.45 Therefore, both statins and BPs can act as anti‐hypertrophic agents in different experimental models but the exact mechanisms are not clarified yet. The gene discussed is FDPS; the disease is hydrops fetalis.