IL‐33 belongs to the IL‐1 family of cytokines.15 Depending on the experimental model and the pathophysiological context IL‐33 can act either pro‐ or anti‐inflammatory.3, 16, 17, 18, 19, 20 In the heart, IL‐33 is believed to be cardioprotective as it was shown to possess anti‐hypertrophic and anti‐apoptotic properties in animal models of pressure overload or myocardial infarction, respectively.21, 22, 23, 24. Here, IL33 is linked to myocardial infarction.