Interestingly, these two candidate driver lncRNAs RP11‐571M6.8 and NKX2‐1‐AS1 were mutually exclusive with a common gene CDKN2A with frequent genetic alterations (> 10%) (Fig. 5G–I) in GBM and LUAD, respectively, affecting the same cancer hallmark ‘Insensitivity to Antigrowth Signals’. The gene discussed is CDKN2A; the disease is cancer.