CDKN2B and cancer: For example, in GBM, amplification of RP11‐745C15.2 and deletion of CDKN2B‐AS1 were both associated with the hallmark pathway of ‘ceramide biosynthetic process’, which was reported to promote apoptosis in glioblastoma (Sordillo et al., 2016), whereas, in PRAD, deletion of lncRNA AC003102.3, RGMB‐AS1, and DLG5‐AS1 was all related to the hallmark pathway of ‘Urogenital System Development’, during which the dysfunction in cell lineage specification predisposed prostate epithelia to hyperplasia and cancer (Brechka et al., 2016).