Moreover, we have previously demonstrated that pFUS alone (no MSC infusions) did not alter endogenous murine IL‐10 levels or AKI outcomes despite the numerous other molecular changes associated with sonication.17 It is not immediately clear why pFUS‐associated molecular changes alone were insufficient to influence AKI outcomes, or if they also induce homing of endogenous MSC, but AKI outcomes are only changed by infusions of exogenous MSC. This evidence concerns the gene IL10 and acute kidney injury.