In conclusion, pFUS increased the therapeutic potency of MSC to reduce tubular injury and improve renal function in a cisplatin AKI model though pFUS‐induced up‐regulation of renal INFγ that stimulated additional MSC production of IL‐10; this pathway is unrelated to the increase of MSC homing to pFUS‐treated AKI kidneys. Here, IL10 is linked to acute kidney injury.