This is difficult to say with certainty since AKI in the IFNγ‐KO mice might not be the same disease despite similar levels of injury being reported between KO and WT mice.50 Additionally, the cohorts in this study did not respond to cisplatin with as severe of AKI as previously observed.17 However, it is clear that further increasing renal IFNγ concentrations with pFUS in WT mice did not yield analogous elevations in MSC IDO. Here, IDO1 is linked to acute kidney injury.