TP53 and cancer: Furthermore, p53 activation by nutlin‐3, a known activator of p53 (Vassilev et al., 2004), led to increased FDPS mRNA similar to the observed p21 increase and led to binding of p53 on the p53 binding site previously described on FDPS promoter in cancer cells (Laezza et al., 2015; Figure 6f–g).