Although further investigations are needed to examine how CCD‐specific IgE may inhibit allergic effector responses, Doenoff and colleagues have explored the role of IgG antibodies as blocking antibodies.65, 66 Through in vitro studies, rabbit anti‐schistosome IgG was found to cross‐react with allergens such as latex65 and peanut extract.66 The authors proposed that anti‐schistosome IgG antibodies may block IgE‐induced allergic responses and therefore prevent the manifestations of allergic disease.66 Here, IGHE is linked to allergic disease.