Moreover, we have shown that some cardiovascular biomarkers, such as copeptin (CT-pro-AVP), pro-atrial-natriuretic-peptide (MR-pro-ANP), and pro-adrenomedullin (MR-pro-ADM) may be altered in conditions related to unexplained falls and syncope such as orthostatic hypotension [8, 9]. This evidence concerns the gene NPPA and orthostatic hypotension.