COG2 and Sepsis: PCSK9 binds and degrades the LDL receptor which results in increased LDL-C levels in the blood, and it has been shown that increased PCSK9 levels in human sepsis patients are associated with reduced endotoxin clearance in cultured human hepatocytes.[18,19] Our group has also shown that reduced LDL-C levels are a risk factor for the future development of sepsis.[20]