Increased protein levels of several cytokines and mediators of the inflammatory response have also been reported in the CSF in ALS, including IL-1, IL-1β, IL-6, IL-8, IL-12, IL-15, IL-17A, IL-18BP, IL-23, RANTES, chemokines, and MCP1 [60–69]. This evidence concerns the gene IL18BP and amyotrophic lateral sclerosis.