HNRNPR and neurodegenerative disease: On the other hand, due to the increase importance of the inflammatory response in the pathogenesis of neurodegenerative disease (Wyss-Coray and Mucke, 2002; Block and Hong, 2005; Glass et al., 2010), it was particularly interesting to note that cells depleted by hnRNP Q and hnRNP R showed a prominent disruption of this pathway.