If the IRS were subdivided by degree of tumor differentiation, moderately-differentiated tumors appeared to express more OX40L on malignant cells than did well- or poorly-differentiated ones [IRS median (range): 0 (0–140), grade 1; 55 (0–120), grade 2; 0 (0–104.4), grade 2/3 + 3, p = 0.041 and p = 0.050, respectively)] (Figure 4D). Here, TNFSF4 is linked to neoplasm.