In fact, the tumor cell-line HepG2 presents gain of genomic material at 6q24 (Figure 1), the lowest degree of P1 promoter methylation (Figure 2), and still the transcript and expression level of PLAGL1 is similarly low to that of the other hepatoma cell lines (Figure 4A and Figure 6A). This evidence concerns the gene PLAGL1 and hepatocellular carcinoma.