YAP1 gene locus 11q22 is found amplified in myriad tumors spanning liver, lung, esophagus, mammary gland carcinomas, oral squamous cell carcinoma and medulloblastomas [8–14], whereas YAP1 overexpression has been identified in lung, colorectal, hepatocellular, ovarian, prostate and pancreatic cancer cells [15–17]. Here, YAP1 is linked to oral cavity squamous cell carcinoma.