In line with this possibility, neuronal tissue abnormalities have been reported in WT SOD1 transgenic mice [19], and abnormally high levels of SOD1 transcripts were reported in spinal cord, brain stem and lymphocytes of sporadic ALS patients [20], although it remains to be investigated whether these conditions are associated to overstimulation of Rac1-mediated pathway for lamellipodia. Here, RAC1 is linked to amyotrophic lateral sclerosis.