EZR and cancer: Alk was selected for validation as several previous studies have implicated this gene in modulating alcohol-drinking behavior (Heberlein et al., 2010; Lasek et al., 2011; Dutton et al., 2017); Wnt5a, Camk2a, and Ezr were selected for validation because components of the “Proteoglycans in Cancer” pathway identified as significantly altered by ethanol withdrawal by KEGG pathway analysis of our ChIP-seq results (Figure 4).