In vivo, combined treatment of OT1-PTM with OT2-PTM T cells mediated enhanced tumor control over PTM-transduced OT1 T cells, OT1 plus OT2 T cells and OT1 plus PTM-OT2 T cells in the EG7-PD-L1 model (Figure 2F). The gene discussed is CD274; the disease is neoplasm.