The relevance of the CBM complex and MALT1 protease activity were formally shown by silencing of the individual CBM components in ABC DLBCL (112, 113) and MCL (104) cell lines, or by inhibition of MALT1 proteolytic function in ABC DLBCL (113, 114), MCL (104), and CLL (110) cell lines. The gene discussed is MALT1; the disease is mantle cell lymphoma.