The relevance of the CBM complex and MALT1 protease activity were formally shown by silencing of the individual CBM components in ABC DLBCL (112, 113) and MCL (104) cell lines, or by inhibition of MALT1 proteolytic function in ABC DLBCL (113, 114), MCL (104), and CLL (110) cell lines. This evidence concerns the gene MALT1 and B-cell chronic lymphocytic leukemia.