NR0B1 and polycystic ovary syndrome: Our finding of a link between rs709154 and rs1151996 in PPARG, which lies in an intron of the gene, and risk of PCOS may be explained by the fact that the encoded protein functions as a nuclear hormone receptor to play a crucial role in lipogenesis, cell differentiation, inflammatory cytokine production, glucose homeostasis and insulin sensitization (36).