MTHFR and polycystic ovary syndrome: Further we detected the following genotype distribution were associated with decreased PCOS risk: GA genotype at rs9340799 (P < 0.0001) in ESR1, TA genotype at rs709154 (P < 0.0001) in PPARG, CA genotype at rs2272046 (P < 0.0001) in HMGA2. Moreover, GA genotype at rs1999805 (P = 0.013) in ESR1 and TT genotype at rs1801133 in MTHFR (P < 0.0001) correlated with elevated PCOS risk (Table 4).