CRP and alcohol dependence: While our data specifically adds validity to the use of CRP as a biomarker of alcoholic AP, they also strongly implicate acute phase proteins in general, as 16 distinct “positive acute phase” proteins (SAA, ORM, AGT, LBP, CRP, FGA, FGB, FGG, SERPINA3, F8, SERPINA1, C9, C1, ITIH3, vWF, and SERPING1), and two “negative acute phase” proteins (Ritchie et al., 1999) (ALB and TF) emerged in our list of proteins elevated and decreased, respectively in alcoholic AP.