RP1 and autoimmune disease: Notably, the included trials presented evidence of immunologic regulation effects in multiple models of autoimmune disease as follows: Astragalus membranaceus (Qu et al., 2010; Jin et al., 2013; Zhao et al., 2016), Ginsenoside Rp1, Ginsenoside Rb1, and Ginsenoside metabolite compound K (Bae et al., 2012; Chen et al., 2014a, 2016; Jhun et al., 2014) from Radix Ginseng increase number of Tregs through promoting Foxp3 expression and further an increase of endogenous Treg population, or the adaptive transfer of compatible exogenous and possibly autologous functional Tregs (Bae et al., 2012).