SLC6A4 and Anxiety: In a prior study, we found that developmental LB led to significant short-term changes in anxiety-related behavior and brain gene expression; specifically, developmental MCH exposure caused decreased open arm time on the EPM, decreased brainstem SERT expression, and increased hippocampal 5Htr1a and Crhr1 expression 3 weeks after final MCH exposure (Caulfield et al., 2017).