AKT1 and schizophrenia: Interestingly, CREB is a substrate for Akt and GSK3β phosphorylation: Akt at Ser133 (Li et al., 2011), while GSK3β at Ser129 (Horike et al., 2008); and (3) besides these studies that implicate CREB in schizophrenia, evidence is provided by patients’ postmortem pathological studies.