Activated Akt directly phosphorylates CREB at Ser133 in striatal neurons (Brami-Cherrier et al., 2002); (v) CREB stimulates the expression of a number of genes containing CREs (5′-TGACGTCA-3′) in their promoter regions (Montminy, 1997), which may be associated with schizophrenia such as D1R, serotonin transporter, and synapsin 1 (Meyer et al., 1993; Montminy, 1997). This evidence concerns the gene DRD1 and schizophrenia.