The protein and gene levels of CREB and the binding activity of CREB to CRE in schizophrenic brains were significantly decreased in the cingulate gyrus (Yuan et al., 2010; Ren et al., 2014), an integral brain limbic system structure, which is involved with emotion, learning, and memory and found to be smaller and with lower neural activity in people with schizophrenia. The gene discussed is CREB1; the disease is schizophrenia.