In animal models of schizophrenia, PKA activity and CREB phosphorylation in the NAc are decreased, and treatment with antipsychotics increases CREB activity in the NAc, and this neuro-adaptive response facilitates the recovery of sensorimotor gating (Culm et al., 2004), which is seriously disrupted in schizophrenic patients. The gene discussed is CREB1; the disease is schizophrenia.