Importantly, key mechanistic data suggest that miR-378-mediated inhibition of GOLT1A, which is involved in the fusion of transport vesicles with the Golgi membrane, plays a critical role in tamoxifen resensitization in vitro, which is further corroborated by clinical data demonstrating increased relapse-free survival in breast cancer patients with low GOLT1A expression. The gene discussed is GOLT1A; the disease is breast cancer.