The upregulation of miR-27b sensitization to tamoxifen in ER+ breast cancer cells was further associated with the suppression of direct targets, NR5A2/LRH1 and CREB1, which are implicated in tamoxifen resistance via the induction of ERα and aromatase, respectively [72, 90]. The gene discussed is NR5A2; the disease is breast carcinoma.