MECOM and acute myeloid leukemia: To assess whether PIP/56-1 and PIP/56-2 interfere with recruitment of EVI1 to the GPR56 promoter region, we performed chromatin immunoprecipitation (ChIP) assays with anti-EVI1 antibody and primers specific to the EVI1-binding region of the GPR56 promoter in the EVI1high AML cell line UCSD/AML1 treated with various PIPs.