MECOM and acute myeloid leukemia: To further evaluate the effects of GPR56 PIP treatment on hematopoietic progenitor cells, the gene expression profile of PIP/56-1-treated UCSD/AML cells was compared with that from the gene sets of hematopoietic progenitor cells from Evi1-deficient mice by GSEA analysis11 (Supplementary Fig. S3d,e).