To confirm these results, expression of several EVI1-targets [ANGPT1, thrombopoietin receptor (MPL), GATA2, creatine kinase, mitochondrial 1 (CKMT1), RUNX1, and BCL2 like 1 (BCLX-L)]26,27 and non-EVI1-target genes [transferrin receptor (TFRC), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and 18SrRNA] were determined in two EVI1high AML cell lines following administration of these PIPs by quantitative RT-PCR. Here, RUNX1 is linked to acute myeloid leukemia.