Hepatic PPARγ2 stimulates the uptake of hepatic fatty acids, re-esterification of fatty acids into monoacylglycerol, and formation of lipid droplets through upregulation of fatty acid translocase (CD36), fatty acid-binding protein 4 (FABP4), monoacylglycerol acyltransferase 1 (MOGAT1), perilipin 2 (PLIN2), and fat-specific protein 27/cell death-inducing DFFA-like effector C (FSP27/CIDEC), which promote hepatic steatosis. Here, PLIN2 is linked to fatty liver disease.