We previously reported that JMJD2B promotes PPARγ2 expression via erasing H3K9me2/me3 on the PPARγ2 promoter, which stimulates adipogenesis in 3T3-L1 preadipocytes20; however, the role of JMJD2B in the development of hepatic steatosis has not been elucidated. Here, PPARG is linked to fatty liver disease.