In addition, concomitant with increased PPARγ2 expression, JMJD2B overexpression promoted the expression of PPARγ2 steatosis target genes, including CD36, FABP4, PLIN2 and CIDEC. Furthermore, the ChIP assay revealed that binding of PPARγ2 on PPREs of steatosis target genes, such as CD36 and PLIN2, was enhanced in JMJD2B-overexpressing HepG2 cells. Here, KDM4B is linked to steatosis.