Trazodone has been shown to reduce ATF4 levels without affecting eIF2α in cell culture (CHO-KI CHOP:luciferase cells and Chinese hamster ovary (CHO); HEK293 cells, and mouse neuroblastoma N2A cells) that were treated with tunicamycin, suggesting that it works downstream of PERK and eIF2α phosphorylation [61]. This evidence concerns the gene EIF2A and neuroblastoma.