Inflammation related genes including S100A8, S100A9 and CHI3L1 are elevated in the hippocampus in schizophrenia and perivascular macrophages (CD163+) have been identified in the lumen of blood vessels and surrounding the endothelial cells in at least one schizophrenia hippocampus [21]. The gene discussed is CHI3L1; the disease is schizophrenia.