Rudnick et al. reported that the cellular uptake level of antibodies inversely correlated with the affinity toward HER2 because C6.5-IgG is having the highest affinity (KD = 2.7 × 10–8) had a lower uptake than trastuzumab did in SK-OV-3 human ovarian carcinoma tumor xenograft at 24 and 120 hrs post-injection16. This evidence concerns the gene ERBB2 and neoplasm.