In order to identify whether NLRP1 activity in the non-hematopoietic or hematopoietic compartment was detrimental during DSS-induced colitis, we generated reciprocal bone marrow chimeras, whereby WT and Nlrp1−/− mice were lethally irradiated and reconstituted with either WT or Nlrp1−/− bone marrow. This evidence concerns the gene NLRP1 and colitis.