To further evaluate the effects of CA9 inhibition and APE1/Ref-1 inhibition in PDAC cells, we employed the SLC-0111 analog, FC12-531A, which yielded similar results to SLC-0111 in the tumor cells in this model, but with substantially lower concentrations needed to achieve similar effects on tumor growth inhibition (3 μM FC12-531A vs. 50 μM SLC-0111). The gene discussed is APEX1; the disease is neoplasm.