Overexpression of REST/NRSF and/or dysregulation of its cellular expression pattern is related to several neuropathies, including medulloblastoma8,9 (a malignant pediatric brain tumor that originates in the cerebellum or posterior fossa10), glioblastoma11,12, Huntington’s disease13–16, neuropathic pain17,18, and Parkinson’s disease19, as well as potentially autism20 and fibromyalgia21. This evidence concerns the gene REST and neuropathy.