SOD1 and amyotrophic lateral sclerosis: For more than 10 years, the complex pathogenesis of ALS has been evaluated with a variety of gene expression profiling methods, such as microarrays and RNA sequencing (RNA-Seq), coupled with whole-tissue or laser-capture microdissected tissue at several stages of disease in mutant SOD1 ALS mouse models3–8 and in postmortem patient tissues9–14.