TP53 and cervical carcinoma: In conjunction with the cellular ubiquitin ligase E6AP, E6 oncoprotein could degrade tumor suppressor protein P53 via the ubiquitin-proteasome pathway; meanwhile, E7 oncoprotein could induce retinoblastoma tumor suppressor gene product pRb degradation [72], resulting in disrupting cell cycle regulation and inhibiting apoptosis of cervical carcinoma [73].