A recent study indicated 6-shogaol sensitized gemcitabine treatment and down-regulate NF-κB activity with its target genes COX-2, cyclinD1, survivin, cellular inhibitor of apoptosis protein-1 (cIAP-1), and X-linked inhibitor of apoptosis protein (XIAP) expression in pancreatic cancer cells. This evidence concerns the gene XIAP and familial pancreatic carcinoma.