H3K9 demethylases LSD1 and JMJD1A are related to tumor progression and metastasis in several cancer types, including colorectal and leukemias [32,33], as the balance between methylases and demethylases are critical for epigenetic changes, exploring these enzymes as potential therapeutic targets will have clinical interest in the future. The gene discussed is KDM1A; the disease is leukemia.