CREB1 and infection: For example, cAMP response element-binding protein (CREB) can bind to certain DNA sequences to increase or decrease the transcription of genes containing cAMP-responsive elements.[31] In addition, CREB can promote anti-inflammatory immune responses by inhibiting NF-kB activity and producing T-regs, thereby inhibiting inflammation, tissue damage, and autoimmune responses, or pathogenic infection factors.[32]