GPT and hepatocellular adenoma: Our models successfully recapitulated this feature of hepatocarcinogenesis, since male models displayed enhanced serum ALT levels [DEN 10/CCl4 (p = 0.020); DEN 50/CCl4 (p = 0.001)], preneoplastic AHF with increased size (only in DEN 10/CCl4 model, p<0.001), area (p = 0.008, for both models) and enhanced HCA multiplicity [DEN 10/CCl4 (p = 0.007); DEN 50/CCl4 (p = 0.020)] compared to females (S5 Fig).