The SCN3A (OMIM 18239) gene on 2q24.3 is a sodium-dependent channel protein that plays a major role in pulmonary artery smooth muscle and cardiomyocyte excitation.[44] Moreover, this protein acts as a coupler of protein-protein interactions in a centrosome-cilium formation that is distinctly related to congenital heart abnormalities.[45] The role of embryonic cilia in developing congenital heart malformation is well established, making a role in TOF development plausible. This evidence concerns the gene SCN3A and congenital heart malformation.