Co-administration of soluble VEGFR1 inhibited the beneficial effects from PlGF.[13] However, it has been reported that PlGF-VEGFR1 signaling plays an important role in decreasing apoptosis of tumor cells, which set VEGFR1 apart from VEGFR2.[14] Studies suggested that VEGF-VEGFR1 signal transduction pathway mediated the cardioprotection of ischemic preconditioning. Here, PGF is linked to neoplasm.