PIK3CA and breast cancer: Somatic mutations in AKT1, PIK3CA PTEN and TP53 genes were found at high frequency in breast cancer, with PIK3CA as 26.4%, TP53 as 24.7%, PTEN as 3.8% and AKT1 as 2.8% in the Catalogue of Somatic Mutations in Cancer (COSMIC) database [4].