HES5 and cancer: At 1p36.33-p36.32, thirteen genes were identified the first three genes are C1orf86, FAM213B, and HES5. C1orf86 at 1p36.23 (7809383–7905274) were identified four genes gain e.g CAMTA1, PER2, UTS2 and VAMP3. UTS2 involves signalling pathways and UTS2 mutation is associated with different types of cancer (Fig 4A–4D).